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Salmeterol

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Q: Will missing my regular doses of asthma prevention medication undo the long-term effects of the medicine?
As in it preventing the severity of asthma symptons. Lately when my inhaler runs out its never convinient to get a refill before im due to take my next dose, this happened recently (due to my lack of preperation). Cud this be part of the reason my asthma symptons improve for a couple of weeks then get gradually worse for a few weeks and so on?

My preventer inhaler is Seritide Accuhaler 250, ingrediants include salmeterol (long-acting bronchodilator) and fluticasone (corticisteroid), i take 2 doses twice a day

A: That is a decent dose of Seretide and being a steroid MUST NOT be stopped suddenly. Not only does this put you at risk of an asthma episode but, since your body is used to quite high dose synthetic steroid it does not respond normally and produce its own steroids so well when they are required.

Q: I am 62. Last January my Asthama/COPD culminated into Broncho-pneumonia and later pneumothorax.?
I had to be in the ICCU for a fortnight.Right now I take regularly Salmeterol & Fluticasone Propionate inhaler(Seroflo 250) twice a day and Montek plus in the evening. I have developed Dry Skin and itching problem in the lower leg which Montek LC used to relieve but Montek plus does not.Since one month I do not have breathing problem but the Doctor asks to take medicine regularly. Secondly I get exhausted easily after the ICCU episode. Please enlighten.

A: when i got asthma symptoms i went straight for Ayurvedic treatment and now cured.

Q: why are my ankles and feet swelling up?
Recently discharged from the hospital w/COPD emphysema exacerbation and a minor bout with pneumonia.
Discharge meds were cefuroxime(Ceftin)-antibiotic500mg
simvastatin(Zocor)-cholesterol10mg
prednisone(Deltasone)draw down medication over 8days30/20/10/5mg 2days @
clonazapam(Klonopin0.5mganti anxiety/sleep aid/relaxant
Salmeterol Discus(Advair)/Combivent Inhaler(albuterol ipratroprium)
& a multivitamin
Now-still taking the prednisone(5th day)w/3 to go. While in the hospital(10 days “I had no problem with swollen ankles or feet at all”.
Now that I am home 7days my feet and ankles are really swollen-not really tender but will retain an impression if I press on them. Also, I have been experiencing burning stabbing pains intermittently in the upper front portion of my right leg from the crotch joint to the knee.Several times these pains were serious enough to be debilitating.
I should mention that if I squeeze my foot or ankles on the right led I can create the burning stabbing painful sensation in my upper leg.
I am also on 2 ltr oxy 24/7 and am relatively sedentary(couch potato) and housebound.
Is it possible that Some of the medications that I am on could be causing the problem?
My appetite is voracious and my attitude is extremely positive except for the fact that I have fat feet! I am very slim-weighed 98lbs when I entered the hospital and gained 11 lbs there and am still picking up weight but I feel now that some of it might be water retention. oh-I should mention that I have no known allergies and am male/64 years old 5′11″
Has anyone had similar experiences as mine? I most likely will be speaking with my PCP soon so please don’t suggest that I call my MD- just wondering if I might be reacting to some of the medications. Thanks for considering replying to my question… Tony Zalvis III (me)

A: It is possible that the swelling is related to the prednisone, though this effect is usually only seen after prolonged use (for a COPD exacerbation I’m guessing you haven’t been on it for months; your dose also isn’t that high). Keep monitoring your weights daily, and as you state you are likely speaking with your PCP, just mention the swelling to him or her. Most likely you’ll either be told to wait and see if it subsides or be given a short bout of furosemide (a diuretic / water pill). The sedentary lifestyle also does not help, though I understand your COPD may make physical activity difficult, and there are many other potential causes of the swelling (your physician will help work through these when you see him or her).

Q: can i take diflucan if im on a asthma puffer?
i have a bad cough so the doctor gave me this “Seretide accuhaler” which contains 250micograms of FLUTICASONE PROPIONATE and 50 micorgrams of SALMETEROL (AS XINAFOATE)

i jsut copied that off the box. i have a horrible itch down there with redness and want to take a diflucan, but am worried if i take it it may have a reaction with the puffer? i only use the puffer before i go to sleep.

could a nurse or doc please help me out?
thanks

A: There are no interactions between those, you are fine to use both.

Q: How does SYMBICORT increase the risk of asthma related death?
I dont understand fully what this mean can anyone explain.My dr. prescribed me this but Iam afraid to try it.

WARNING: Long-acting beta2-adrenergic agonists may increase the risk of asthma-related death. SYMBICORT should only be used for patients with asthma not adequately controlled on other asthma-controller medications (eg, low- to medium- dose inhaled corticosteroids) or whose disease severity clearly warrants initiation of treatment with two maintenance therapies. Data from a large placebo-controlled US study that compared the safety of another long-acting beta2-adrenergic agonist (salmeterol) or placebo added to usual asthma therapy showed an increase in asthma-related deaths in patients receiving salmeterol. This finding with salmeterol may apply to formoterol (a long-acting beta2-adrenergic agonist), one of the active ingredients in SYMBICORT (see WARNINGS in full Prescribing Information)

A: Good for you for reading the warning and questioning your prescription. Basically, it means the following:

When you use this long-acting drug, it works in your system for about a day. If you happen to have an asthma attack close to your next scheduled dosing, you need to use a rapid-acting drug like Albuterol to stop the asthma attack because Symbicort takes too long to start working. Albuterol works in about 15 minutes, whereas Symbicort can take up to 10 hours to start working. If you don’t have a quick-acting drug, the asthma attack may be fatal.

That warning means that at least someone died while using the medication. The death might have been related to the use of the drug, or it might not have been. There’s no way to know for sure. It is most likely safe to use the drug. It would have been pulled from the market if it was too risky.

However, the warning states, “SYMBICORT should only be used for patients with asthma not adequately controlled on other asthma-controller medications…or whose disease severity clearly warrants initiation of treatment with two maintenance therapies.” So I have to ask, have you tried other asthma medications? Did they work? Do you have a rapid-acting drug? If you have tried other meds that did work then ask your doctor why the prescription was changed. If you don’t have a rapid-acting drug, tell the doctor to prescribe one. You should even print this posting and take it with you for reference, as well as the product packaging. If your doctor doesn’t explain his actions or won’t try other drugs, get a different doctor.

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