Avandia
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Q: What time of day is it best to take avandia, morning or before dinner?
A: Your dose of Avandia may be taken once a day in the morning or divided in half and taken in the morning and evening, with or without food.
RN
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ava1532.shtml
Q: Is it advisable to take alpha betic alongside glucophage, avandia and dionil?
A: No, the other three drugs you listed are not in the correct order,
Q: Can any one tell about Avandia?
The Dr has prescribed avandia, there is a history of heart disease, and stroke. Would it be wise, for me to take it.
A: Every drug has their possibilities for complications. As long as you feel comfortable with your doctor and his decision (and you have talked about all possibilities) then try it. If you still don’t feel it wise to take it, then get a second opinion. Have you tried other medications to lower your blood glucose? See if you can explain to your doctor about a change of drug. Good luck!
Q: confused on meds/ Lantis and avandia. Have lost sight in one eye due to swelling and macular edema.?
Avandia causes macular edema, swelling of eyes. If not taken will bottom out in diabeic coma. Is there no other med to replace advandia? Also take lantis by shot 30 mg pm.
A: I don’t know they’ve found the mechanism by which avandia gives macular degeneration. Lantus is a long acting insulin to kind of force your cells to uptake glucose properly. You have type II diabetes but you could easily be treated on insulin only regime or insulin + tablets or just tablets. Probably they’ve discontinued use of avandia because of your eye worries and put you on actrapid/novarapid three times daily plus lantus. This is the closest you can get to the natural regulation of blood sugars.
Q: why prescribe Avandia rather than long acting insulin by injection for type 2 diabetic control?
A: Type 2 diabetics are producing enough insulin, it’s just that their bodies are unable to utilize it. Avandia frees up that insulin for the body to use, and without the risk of hypoglycemia.
Injected insulin has to be carefully monitored and errors can have terrible consequences.
Q: has anyone taken avandia, i hear that it makes you gaing weight?
I just was recently diagnosed as a type 2 diabetic and since have changed my eating habits and my exercises.The doctor told me i should lose some weight and i’m trying however i hear that avandia makes you gain some weight. If any one has taken this could you please offer any suggestions. i just can’t seem to lose weight.
A: Avandia is an insulin sensitizer, which means that it increases the effect that the insulin in your body (or the insulin your inject, the drug doesn’t care) has on you. Now, one of the things that insulin does is tell your body to take sugar up from the blood into cells where it can be metabolized and stored rather than filtered out through the kidneys, so yes, you will be able to use more of the calories from the food you eat and will tend to gain weight compared to an uncontrolled diabetic who is peeing out sugar due to high levels in the blood.
It’s also true that loosing weight can help type 2 diabetics control their blood sugar better. So why would be give a drug that seems to do something entirely opposite to the effect we would want? Well, because it also lowers serum glucose levels, which is the most important thing. First we try to get the blood sugar under control, then we worry about weight loss. So take your meds as your doctor prescribes them, talk to him about it, check your blood sugar to see how you’re doing, and you can work with your doctor to adjust your diet and exercise regimen to loose weight even while on the meds.
Q: Can you get pregnant from taking avandia and byetta?
A: Are you asking if Avandia (I’m on it) and Byetta (don’t know what that is) help you get pg if you’re TTC? Yes, Avandia for sure can b/c it will help with insulin resistance (IR) which, in turn, helps your hormones.
Do you have PCOS? I have it with IR and that’s why I’m on Avandia, Sprionolactone (Aldactone), and low-dose monophasic BC pills.
Q: Avandia or Actos, raises blood glucose readings?
Has anybody else had Avandia, Actos or another med raise your blood glucose levels, instead of lowering them like it is supposed to?
- Without changing your eating habits
- Without changing your daily routine
- Numbers went wild or went up consistently
What did your doctor tell you to do? What other information did you find out? What can be done to counteract the effect?
A: i was on avandia for about 2 yrs and my sugar was up and down and i got really dizzy after eating. the doc put me on actos 30mgs once a day and i also went to a diabetic clinic for a 4 week course which really showed me how to improve my eating and excersize program. with regular eating the right portions of foods and snacks i found i am a lot better and have more energy than i did before. the snacks help control your sugar especilly before bedtime. even if you are not hungry have a piece of fruit or a few crackers and a chunk of cheese to maintain the blood sugar. if you don’t eat right the liver kicks in and your sugar will rise because it thinks you need more insulin in your body. check with a diabetic clinic near you and you will be surprized how many things you don’t know about this disease.it is really well worth it.
Q: I have type two diabeties I just seen the FDA warnings for avandia?
I have type two diabeties I just seen the FDA warnings for avandia – I take 2 mg 1x daily when I go off my of it for any length of time and resume I get severe headaches especially in the nape of my neck/skull and a back ache in my upper back. Has anyone had these expiriences ?
A: I too was diagnosed with diabetes and was put on Avandia, I had to be taken off of it because it was affecting my kidneys. Best to speak with your doctor and ask for a different kind or better dosage of your meds. Good luck sweetie 
Q: does anyone know the long term affects of metformin and avandia for diabetes?
what kind of reactions do you have with these drugs. i just started taking them i feel nausiated
A: Perhaps you can ween yourself off the meds with a proper diabetic diet.
Diet Guidelines
http://www.diabetes911.net/readit/chapter10.shtml
Blood Sugar Management
http://www.dlife.com/dLife/do/ShowContent/blood_sugar_management/
Q: Can i get pregnant while taking avandia and metformin?
A: i don’t know for sure about the avandia…but metformin HELPED me get pregnant. in my opinion you can get pregnant on ANY medication unless it is chemically putting you through menopause!
Q: does avandia used for diabetes have an increased risk of heart attack ?
saw it in the medscape.
A: This warning was a result of a retrospective study published recently which showed increased heart attack risk with Avandia. This study was funded by avandia’s competitor Pfizer. This is a risk associated with all drugs in that class of medication (actos and avandia), and has been known about since the drug was approved.
Prescription drugs are dangerous, which is why they are not readily available to the public and only available when prescribed by a physician and dispensed by a pharmacist who have a combined 16+ years of education in the field. This is not new information for them, this is just media hype in an effort to gain market share. It’s an advertising campaign.
This risk has been known about since the drug was approved. If you look at the study cited it merely analyzed the studies done to approve the drug. The FDA alert says this:
“The U.S. Food and Drug Administration (FDA) is aware of a potential safety issue related to Avandia (rosiglitazone), a drug approved to treat type 2 diabetes. Safety data from controlled clinical trials have shown that there is a potentially significant increase in the risk of heart attack and heart-related deaths in patients taking Avandia. However, other published and unpublished data from long-term clinical trials of Avandia, including an interim analysis of data from the RECORD trial (a large, ongoing, randomized open label trial) and unpublished reanalyses of data from DREAM (a previously conducted placebo-controlled, randomized trial) provide contradictory evidence about the risks in patients treated with Avandia.”
“Since the drug was approved, FDA has been monitoring several heart-related adverse events (e.g., fluid retention, edema and congestive heart failure) based on signals seen in previous controlled clinical trials of Avandia alone and in combination with other drugs, and from postmarketing reports. FDA has updated the product’s labeling on several occasions to reflect these new data, most recently in 2006. The most recent labeling change for Avandia also included a new warning about a potential increase in heart attacks and heart-related chest pain in some individuals using Avandia.”
Note that it says the FDA is aware of this, not that this is new data for the FDA. I will repeat again the sentiment that this is just an over-hyped media quoting a study that has already been done, and was already known by health care professionals when they made the decision to start you on Avandia.
Continue taking it until you have an opportunity to discuss it with your physician.
Q: Recently diagnosed Type ll Diabetes. Taking Avandia. Prescribed Metformin, should I take it?
I have been able to control my blood suger level with a good diet and exercise. I’m at 109 I would like some feedback. I don’t like the side effects of the Metformin.
A: You will need less medicine with this and will not need merformin.
These pranayam exercises will help control the diabetes and the side effects.Build up the timing gradually.If you feel tired or dizzy, stop and resume later(after about a minute).The benefits will be noticed in weeks as the sugar level is checked daily.Over the long term the diabetes will be in full control and the medicine can be reduced in consultation with the doctor.
Kapalbhati -(Do it before eating) Push air forcefully out through the nose about once per second. Stomach will itself go in(contract in). The breathing in(through the nose) will happen automatically. Establish a rhythm and do for 20 to 30 minutes twice a day.(Max 60 min/day)
Children under 15 years – do 5 to 10 minutes twice a day.
Not for pregnant women. Seriously ill people do it gently.
Anulom Vilom –
Close your right nostril with thumb and deep breath-in through left nostril
then – close left nostril with two fingers and breath-out through right nostril
then -keeping the left nostril closed deep breath-in through right nostril
then – close your right nostril with thumb and breath-out through left nostril.
This is one cycle of anulom vilom.
Repeat this cycle for 20 to 30 minutes twice a day(maximum 60 minutes in one day).
Children under 15 years – do 5 to 10 minutes twice a day.
You can do this before breakfast/lunch/dinner or before bedtime or in bed.Remember to take deep long breaths into the lungs.You can do this while sitting on floor or chair or lying in bed.
Also everyday, press the centre point of the palm of both your hands 40 times with the thumb and press the tips of all fingers 40 times each.
Also do this: kneel down, breathe out,pull in stomach, keep your both hands on stomach, bend forward and try to touch the floor with your forehead.Do this 3 times to stimulate the kidney and pancreas.
Continue the exercises once a day, after the diabetes is in full control.
Q: Why didn’t the FDA pull Avandia after the heart attack side effect?
A: The Food and Drug Administration is a corrupt an inept agency. They are inextricably interwoven with the pharmaceutical industry. The FDA rarely ‘pulls’ a drug unless attorneys start televising 800 numbers. The FDA much prefers a company to ‘voluntarily’ withdraw a drug. The first drug in this class of thiazolidinediones – troglitazone – was voluntarily withdrawn by the manufacturer. The increased incidence of myocardial infarction (heart attack) with rosiglitazone (Avandia) has been known for years. In theory no sane physician would prescribe this drug at this point in time as the number of adverse trials are growing and they are consistent in their findings. The related drug pioglitazone (Actos) has not been linked to myocardial infarction. There is the question of whether pioglitazone is linked to onset or worsening of heart failure. Unfortunately the medical literature on this is neither clear nor consistent. In answer to your question the FDA is waiting for the manufacturer – GlaxoSmithKline – to voluntarily withdraw the drug. I believe that GlaxoSmithKline will withdraw the drug before the end of this year. If I may be of further assistance please let me know. I wish you the very of health and in all things may God bless.
Q: My doctor prescribed Avandia in October. Now she will not return my calls about my concern for this latest?
study about Avandia leading to cardiac problems. How can I take care of my heart while on Avandia?
A: For the past year I have been encouraging patients to email me rather than call the office. So many calls come through a busy office during a single day that it is not uncommon for a call to be ‘lost’. If you have called 2 or 3 times and not received an answer that would be – in my opinion – a breach of the physician patient covenant. Your concern however is what this recent study means – specifically – will taking rosiglitazone/Avandia lead to heart problems. The internet is a dangerous place and full of mis-information and half-truths. The study in question was a meta-analysis which by definition is statistically ‘invalid’. A meta-analysis ’sums’ up the results of various studies with different designs and end-points. Meta-analysis by its very nature has serious short comings. Such an analysis is utilized to suggest areas where further study is needed not to make direct or certain conclusions. The conclusion was that cardiovascular events and deaths were higher in the rosiglitazone patients but the analysis of the studies in question was flawed, the total number of patients studied ’small’ relative to the end-points, the duration ’short’, and actual numbers were small. For example 18 patients on rosiglitazone had events versus 12 patients not taking the drug or taking other drugs. Mathematically that is a 50% increase but simply because something is statistically ’significant’ does not mean that it is clinically meaningful. The study which led to the universal use of the drug rtPA to dissolve blod clots in those with heart attacks is a good example. The conclusion was that there was a 20% reduction in death. The actual figure was a decrease from 15% to 12% which is a 20% decrease. Stated in another fashion however the increase in survival was 3%. Since there was a 3% incidence of serious bleeding complications the actual benefit of rtPA was quite small. The point is that researchers are capable of manipulating numbers to achieve headlines. The study in question regarding rosiglitazone/Avandia is going to become more of a legal than a medical issue. Companies have been forced to withdraw drugs from the marketplace in similar circumstances. The first drug in this class of drugs which reduce insulin resistance – troglitazone – was withdrawn because physicians ignored well publicized data suggesting that the drug was not appropriate for all patients rather than due to problems with the drug itself. The two remaining drugs in this very important class are rosiglitazone/Avandia and pioglitazone/Actos. I use pioglitazone but not because I believe it to be safer than rosiglitazone. There are repeated references in the medical literature that pioglitazone has been linked to heart failure and yet there is no data to support such claims. The quality of American medicine has declined rapidly over the past 20 years and we no longer rank in the top 20 countries in the world in terms of outcome measures. Nonetheless – studies such as the one you refer to do not help at all – unless you are an attorney. When such news appears you did what you should have done. You were concerned and that is appropriate. The physicians role includes being sensitive to such concerns. The physician should be committed to education which decreases patient anxiety. You did not leap to a conclusion – you consulted your physician – or at least you tried to. If your physician had returned your call you would not have needed to resort to receiving potentially incorrect and harmful information from non-physicians on the internet. The Food and Drug Administration – which I admit is rather weak and does a very poor job – has no intention at this time of placing additional warnings or restrictions on rosiglitazone/Avandia. Until you speak with your physician you should not stop taking the drug. The best way you can take care of your heart is to control your glucose and that is what the rosiglitazone is for. If you would like additional information please let me know although it would help if I knew your age, onset of diabetes, glucose readings, A1C readings. lipid values, cardiovascular risk profile, other medical problems, and other medications. I wish you the very best of health and hope that this may reduce your anxiety until you are able to speak with your physician. May God bless. johnerussomd@jhu.edu
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